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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are typically described as a focus on the practical aspects of design, including the recruitment process and consent, adhering and the use of standard equipment.
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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). 무료슬롯 of heterogeneity is essential for practical trials to be valid, and it also helps to reduce the chance of bias in the results. However too much heterogeneity could lead to issues with the design of the trial.
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The purpose of pragmatic trials is to mimic real-life scenarios and to achieve the highest level of validity externally. They are usually requested by practitioners and policy makers to inform their decision making. They can also be a great way to identify the causality between an intervention and its outcomes. They should, however, not, be used to replace explanatory studies.
The pragmatism idea is controversial and there are doubts regarding whether pragmatic trials could replace explanatory tests or if they should serve as an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate a physiological or clinical hypothesis as well as pragmatic trials that inform policy and practice decisions. They also proposed an approach to pragmatic trials, which they called PRECIS.2 This tool sought to define the elements of a pragmatic study that include recruitment, design and delivery of the intervention, and follow-up.
The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to remember that the majority of these trials were conducted in primary care settings.